5/30/2023 0 Comments Mendeley desktop 1.18That review presented limited information on their methods crucially, it was unclear whether the included studies were assessing PSA in symptomatic or asymptomatic patients nor was it clear whether any were relevant to primary care populations. A range of estimates for the accuracy of PSA was found amongst the ten included studies. The most recent systematic review of the diagnostic accuracy of PSA was published by Harvey et al. However, uncertainty remains about the diagnostic accuracy of PSA for prostate cancer in patients with LUTS. Very large randomised controlled trials of PSA-based prostate cancer screening have been performed these are summarised in a recent systematic review in 2018 that showed a small potential reduction in prostate cancer specific mortality with no change in all-cause mortality and an increased risk of complications from biopsy, overdiagnosis of clinically insignificant prostate cancer, and overtreatment. Patients with an elevated PSA are usually referred to a urologist for diagnostic testing, which may include magnetic resonance imaging (MRI) of the prostate and/or a prostate biopsy. PSA testing is usually performed for one of two reasons: assessing a patient presenting to their general practitioner (GP) or primary care physician with lower urinary tract symptoms (LUTS) or screening for a patient who is asymptomatic but concerned about their risk of prostate cancer. ![]() Prostate-specific antigen (PSA) is a commonly used test for the detection of prostate cancer, identifying patients that may require a diagnostic test. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ![]() If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. ![]() The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
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